In the light of the previous post, the FDA informed healthcare professionals some times ago (July 2008) that serious and sometimes fatal hypersensitivity reactions caused by abacavir therapy are significantly more common in patients with a particular human leukocyte antigen (HLA) allele, HLA-B*5701. Abacavir is sold under the trade name Ziagen and is part of the combination products Epzicom and Trizivir.
FDA reviewed data from two studies that support a recommendation for pre-therapy screening for the presence of the HLA-B*5701 allele and the selection of alternative therapy in positive subjects. Patients who carry the HLA-B*5701 allele are at high risk for developing a hypersensitivity reaction. Avoiding abacavir-containing therapy in patients who carry the HLA-B*5701 allele has been found to reduce the risk of a potentially serious or fatal hypersensitivity reaction.
Genetic tests for HLA-B*5701 are available and all patients should be screened for the HLA-B*5701 allele before starting or restarting treatment with abacavir or abacavir-containing medications. Development of clinically suspected abacavir HSR requires immediate and permanent discontinuation of abacavir therapy in all patients, including patients negative for HLA-B*5701. More information is available here.